Archive | Molecular

Antibody-drug conjugate, Biologic Animation

Antibody-drug Conjugate 3D Molecular Visualization

Protein Description Antibody-drug conjugate or ADC are an important class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer.[1][2][3][4][5][6][7] Unlike chemotherapy, ADCs are intended to target and kill only the cancer cells and spare healthy cells. ADCs are complex molecules composed of an antibody linked to a biologically active […]

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CRISPR, Cas9, Biologic Animation

CRISPR Cas9 3D Molecular Visualization

Protein Description “The RNA-guided DNA endonuclease CRISPR Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate efficient in vivo genome editing. Here, we report the crystal structures of SaCas9 […]

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CRISPR, Cpf1

CRISPR Cpf1 3D Molecular Visualization

Protein Description Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been recently harnessed for genome editing. Here, we report the crystal structure of Acidaminococcus sp. Cpf1 (AsCpf1) in complex with the guide RNA and its target DNA at 2.8 Å resolution. AsCpf1 adopts a bilobed architecture, with the RNA-DNA heteroduplex […]

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Pembrolizumab bound to PD-1

Pembrolizumab 3D Molecular Visualizations

Protein Description “Pembrolizumab (formerly MK-3475and lambrolizumab, trade name Keytruda)[1] is a humanized antibodyused in cancer immunotherapy. It destroys a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1(PD-1) receptor. The drug was initially used in treating metastatic melanoma.” https://en.wikipedia.org/wiki/Pembrolizumab 3D Molecular Visualizations This is a theoretical model of Pembrolizumab bound to PD-1 […]

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DPP4, Medical Illustration

Biologic Animation Showreel 2016

Photo-real 3D medical Animation This is a compilation of footage created by Casey Steffen. Seen here are examples of photo-real 3D medical animations created for surgical device companies, educational institutions, pharmaceutical product launches, and broadcast television. Casey’s professional experience spans over 15 years creating 3D animation combining cutting-edge visual effects techniques used in biggest blockbuster […]

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