GLP-1 Structural Confomration Study

Molecular visualization of GLP-1 movements and stable conformations.

3D Molecular Animation

Study of theoretical stable GLP-1 configurations from Biologic Discovery on Vimeo.

This animation depicts a series of stable configurations of the GLP-1 molecule. Of interest, it appears that the residues with greatest structural mobility just happen to be the residues inactivated by DPP4, (residues 7-8). It’s interesting to think that hormone mobility might be impaired as a result of DDP4 activity, cutting off the tail of GLP-1, removing it’s ability to travel through the blood stream to the insulin. Inhibiting the activity of DPP4 is an important target in the treatment of type-2 diabetes.

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