Archive | February, 2017

radialReload

Radial Reload with Tri-Staple Technology

Radial Reload Medical Animation This 3D medical animation is the center piece for an award winning medical communications app. Created for One World DMG and their client Coviden, this 3D animation depicts unique technologies driving the future of GI stapling. Of importance in this animation was the visualization of pressure changes on tissue during stapling. Comparing older […]

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Antibody-drug conjugate, Biologic Animation

Antibody-drug Conjugate 3D Molecular Visualization

Protein Description Antibody-drug conjugate or ADC are an important class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer.[1][2][3][4][5][6][7] Unlike chemotherapy, ADCs are intended to target and kill only the cancer cells and spare healthy cells. ADCs are complex molecules composed of an antibody linked to a biologically active […]

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EGFR, Biologic Animation

EGFR 3D Molecular Visualization

Protein Description The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine […]

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CRISPR, Cas9, Biologic Animation

CRISPR Cas9 3D Molecular Visualization

Protein Description “The RNA-guided DNA endonuclease CRISPR Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate efficient in vivo genome editing. Here, we report the crystal structures of SaCas9 […]

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CRISPR, Cpf1

CRISPR Cpf1 3D Molecular Visualization

Protein Description Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been recently harnessed for genome editing. Here, we report the crystal structure of Acidaminococcus sp. Cpf1 (AsCpf1) in complex with the guide RNA and its target DNA at 2.8 Å resolution. AsCpf1 adopts a bilobed architecture, with the RNA-DNA heteroduplex […]

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Pembrolizumab bound to PD-1

Pembrolizumab 3D Molecular Visualizations

Protein Description “Pembrolizumab (formerly MK-3475and lambrolizumab, trade name Keytruda)[1] is a humanized antibodyused in cancer immunotherapy. It destroys a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1(PD-1) receptor. The drug was initially used in treating metastatic melanoma.” https://en.wikipedia.org/wiki/Pembrolizumab 3D Molecular Visualizations This is a theoretical model of Pembrolizumab bound to PD-1 […]

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